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KMID : 1123920060200030690
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 3 p.690 ~ p.696
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Antiproliferative effect of Houttuynia cordata Thunb was Associated with the Inhibiton of Cyclooxygenase-2 Expression in Human Breast Carcinoma Cells
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Jung Il-Hong
Jo In-Joo
Park Cheol
Choi Yung-Hyun
Park Dong-Il
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Abstract
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Houttuynia cordata Thunb, well known as ’E-Sung-Cho’ in Korea, is a traditional medicinal plant generally used in Oriental medicine therapy. In the present study, we investigated the effect of water extract of H. cordafa (WEHC) on the growth of human breast carcinoma MCF-7 cells. Exposure of MCF-7 cells to WEHC resulted in growth inhibition and apoptosis in a dose-dependent manner as measured by MTT assay and fluorescent microscope. The anti-proliferative effect of WEHC was associated with a dose-dependent up-regulation of cyclin-dependent kinase inhibitor p21 in a p53-independent fashion. We found WEHC decreased the levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthease (iNOS) expression without significant changes in the expression of COX-1 , which was correlated with a decrease in prostaglandin synthesis. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of H. cordata.
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KEYWORD
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Houttuynia cordata Thunb, MCF-7, p2, COX-2
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